Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction.

ABSTRACT:

Background and aims

We demonstrated that dietary ursolic acid (UA) reduces atherosclerotic lesion size and improves kidney function in diabetic mice. Based on structure-function analyses of naturally occurring UA analogs, we synthesized 23-hydroxy ursolic acid (23-OHUA), a compound with structural features predicted to enhance its bioavailability and anti-atherogenic properties compared to UA. The goal of this study was to determine the anti-obesogenic and atheroprotective properties of 23-OHUA and its mechanism of action.

Methods

We performed chemotaxis assays to determine IC₅₀ of phytochemicals on primed THP-1 monocytes. We fed 12-week old female LDLR^-/- mice a high-fat diet (HFD) or a HFD supplemented with either 0.05% UA or 0.05% 23-OHUA, and measur

SUBMITTER: Nguyen HN 

PROVIDER: S-EPMC6113078 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature