Probiotic supplementation increases obesity with no detectable effects on liver fat or gut microbiota in obese Hispanic adolescents: a 16-week, randomized, placebo-controlled trial.

ABSTRACT:

Background

Numerous studies have shown that there are links between obesity, liver fat and the gut microbiome. However, there are mixed results on whether probiotics could impact the gut microbiome and/or help to decrease liver fat and obesity outcomes.

Objective

This study aimed to determine whether a probiotic supplement (VSL#3^® ) intervention altered gut microbiota and/or gut hormones associated with appetite regulation. The secondary aim of this study was to determine whether VSL#3^® altered body composition and liver fat and fibrosis.

Methods

We conducted a double-blind, randomized placebo-controlled trial in 19 obese Latino adolescents. The intervention consisted of three packets per day of VSL#3^® or a matched placebo for 16 weeks

SUBMITTER: Jones RB 

PROVIDER: S-EPMC6113106 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature