Weight Loss Maintenance and Cellular Aging in the Supporting Health Through Nutrition and Exercise Study.

ABSTRACT:

Objective

The aim of the study was to determine, within a weight loss clinical trial for obesity, the impact of intervention arm, weight change, and weight loss maintenance on telomere length (TL).

Methods

Adults (N = 194) with a body mass index between 30 and 45 were randomized to a 5.5-month weight loss program with (n = 100) or without (n = 94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3-, 6-, and 12-month postbaseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes). We defined weight loss maintenance as having lost at least 5% or 10% of body weight (tested in separate models) from preintervention to postintervention, and having maintain

SUBMITTER: Mason AE 

PROVIDER: S-EPMC6113109 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature