The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells.

ABSTRACT: Studies were undertaken to examine any role for the hepcidin/ferroportin axis in proliferative responses of human pulmonary artery smooth muscle cells (hPASMCs). Entirely novel findings have demonstrated the presence of ferroportin in hPASMCs. Hepcidin treatment caused increased proliferation of these cells most likely by binding ferroportin resulting in internalisation and cellular iron retention. Cellular iron content increased with hepcidin treatment. Stabilisation of ferroportin expression and activity via intervention with the therapeutic monoclonal antibody LY2928057 reversed proliferation and cellular iron accumulation. Additionally, IL-6 treatment was found to enhance proliferation and iron accumulation in hPASMCs; intervention with LY2928057 prevented this response. IL-6 was also

SUBMITTER: Ramakrishnan L 

PROVIDER: S-EPMC6113242 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature