Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex.

ABSTRACT: Brain injuries in the adult mammalian brain are accompanied by a fast neurogenic response inside neurogenic niches. However, this response does not contribute to the generation of new neurons within damaged tissues like the cerebral cortex, which are essentially non-neurogenic. This occurs because injuries create a hostile environment that favors gliogenesis. Overexpression and sequential activation of the ADAM17/TGFα/EGFR signaling cascade are crucial for the generation of this gliogenic/non-neurogenic environment. Here, we demonstrate that chronic local infusion of a general metalloprotease inhibitor in areas of traumatic cortical injury in adult mice moderately increased the number of neuroblasts around the lesion, by facilitating the survival of neuroblasts and undifferentiated progeni

SUBMITTER: Geribaldi-Doldan N 

PROVIDER: S-EPMC6113335 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature