Human Bone Marrow-Resident Natural Killer Cells Have a Unique Transcriptional Profile and Resemble Resident Memory CD8⁺ T Cells.

ABSTRACT: Human lymphoid tissues harbor, in addition to CD56^bright and CD56^dim natural killer (NK) cells, a third NK cell population: CD69⁺CXCR6⁺ lymphoid tissue (lt)NK cells. The function and development of ltNK cells remain poorly understood. In this study, we performed RNA sequencing on the three NK cell populations derived from bone marrow (BM) and blood. In ltNK cells, 1,353 genes were differentially expressed compared to circulating NK cells. Several molecules involved in migration were downregulated in ltNK cells: S1PR1, SELPLG and CD62L. By flow cytometry we confirmed that the expression profile of adhesion molecules (CD49e^-, CD29^low, CD81^high, CD62L^-, CD11c^-) and transcription fa

SUBMITTER: Melsen JE 

PROVIDER: S-EPMC6113396 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature