Monitoring changes in the Gene Ontology and their impact on genomic data analysis.

ABSTRACT:

Background

The Gene Ontology (GO) is one of the most widely used resources in molecular and cellular biology, largely through the use of "enrichment analysis." To facilitate informed use of GO, we present GOtrack (https://gotrack.msl.ubc.ca), which provides access to historical records and trends in the GO and GO annotations.

Findings

GOtrack gives users access to gene- and term-level information on annotations for nine model organisms as well as an interactive tool that measures the stability of enrichment results over time for user-provided "hit lists" of genes. To document the effects of GO evolution on enrichment, we analyzed more than 2,500 published hit lists of human genes (most older than 9 years ); 53% of hit lists were considered to yield significantly stable enric

SUBMITTER: Jacobson M 

PROVIDER: S-EPMC6113503 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature