RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists.

ABSTRACT: Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved. We have previously shown that the hemostatic thrombi formed in response to penetrating injuries consist of a core of fully activated densely packed platelets overlaid by a shell of less-activated platelets responding to adenosine 5'-diphosphate (ADP) and thromboxane A₂ (TxA₂). Hemostatic thrombi formed in RGS10^-/- mice were larger than in controls, with the increase due to expansion of the shell but not the core. Clot retraction was slower, and average packing density was reduced. Deleting RGS10 had agonist-specific effects on signaling. The

SUBMITTER: Ma P 

PROVIDER: S-EPMC6113604 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature