NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice.

ABSTRACT: Autism spectrum disorders are neurodevelopmental conditions with diverse aetiologies, all characterized by common core symptoms such as impaired social skills and communication, as well as repetitive behaviour. Cell adhesion molecules, receptor tyrosine kinases and associated downstream signalling have been strongly implicated in both neurodevelopment and autism spectrum disorders. We found that downregulation of the cell adhesion molecule NEGR1 or the receptor tyrosine kinase fibroblast growth factor receptor 2 (FGFR2) similarly affects neuronal migration and spine density during mouse cortical development in vivo and results in impaired core behaviours related to autism spectrum disorders. Mechanistically, NEGR1 physically interacts with FGFR2 and modulates FGFR2-dependent extracellular

SUBMITTER: Szczurkowska J 

PROVIDER: S-EPMC6113639 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature