Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis.

ABSTRACT:

Objective

To conduct a systematic review and meta-analysis of epidemiological studies investigating the association of arsenic, lead, cadmium, mercury, and copper with cardiovascular disease.

Design

Systematic review and meta-analysis.

Data sources

PubMed, Embase, and Web of Science searched up to December 2017.

Review methods

Studies reporting risk estimates for total cardiovascular disease, coronary heart disease, and stroke for levels of arsenic, lead, cadmium, mercury, or copper were included. Two investigators independently extracted information on study characteristics and outcomes in accordance with PRISMA and MOOSE guidelines. Relative risks were standardised to a common scale and pooled across studies for each marker using random effects meta-analyses.

SUBMITTER: Chowdhury R 

PROVIDER: S-EPMC6113772 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature