Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.

ABSTRACT:

Objectives

To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk.

Design

Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach.

Setting

25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data.

Participants

A discovery set of 37 857 fracture cases and 227 116 controls; with replication in up to 147 200 fracture cases and 150 085 controls. Fracture cases were defined as individuals (>18 years old) who had fractures at any skeletal site confirmed by medical, radiological, or questionnaire reports. Instrumental variable analyses were performed to estimate effects of 15 selected clinic

SUBMITTER: Trajanoska K 

PROVIDER: S-EPMC6113773 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature