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Fabrication of ultra-small monolayer graphene quantum dots by pyrolysis of trisodium citrate for fluorescent cell imaging.


ABSTRACT:

Background

The preparation and biological applications of ultra-small graphene quantum dots (GQDs) with accurate-controlled size are of great significance.

Methods

Here in, we report a novel procedure involving pyrolysis of trisodium citrate and subsequent ultrafiltration for fabricating monolayer GQDs with ultra-small lateral size (1.3±0.5 nm).

Results

The GQDs exhibit blue photoluminescence with peak position independent of excitation wavelength. The quantum yield of GQDs is measured to be 3.6%, and the average fluorescence lifetime is 2.78 ns.

Conclusion

Because of high stability and low toxicity, GQDs are demonstrated to be excellent bioimaging agents. The ultra-small GQDs can not only distribute in the cytoplasm but also penetrate into the nuclei. We ensure that this work will add a new dimension to the application of graphene materials for nanomedicine.

SUBMITTER: Hong GL 

PROVIDER: S-EPMC6113908 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Fabrication of ultra-small monolayer graphene quantum dots by pyrolysis of trisodium citrate for fluorescent cell imaging.

Hong Guo-Lin GL   Zhao Hai-Ling HL   Deng Hao-Hua HH   Yang Hui-Jing HJ   Peng Hua-Ping HP   Liu Yin-Huan YH   Chen Wei W  

International journal of nanomedicine 20180824


<h4>Background</h4>The preparation and biological applications of ultra-small graphene quantum dots (GQDs) with accurate-controlled size are of great significance.<h4>Methods</h4>Here in, we report a novel procedure involving pyrolysis of trisodium citrate and subsequent ultrafiltration for fabricating monolayer GQDs with ultra-small lateral size (1.3±0.5 nm).<h4>Results</h4>The GQDs exhibit blue photoluminescence with peak position independent of excitation wavelength. The quantum yield of GQDs  ...[more]

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