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ABSTRACT: Background
The preparation and biological applications of ultra-small graphene quantum dots (GQDs) with accurate-controlled size are of great significance.Methods
Here in, we report a novel procedure involving pyrolysis of trisodium citrate and subsequent ultrafiltration for fabricating monolayer GQDs with ultra-small lateral size (1.3±0.5 nm).Results
The GQDs exhibit blue photoluminescence with peak position independent of excitation wavelength. The quantum yield of GQDs is measured to be 3.6%, and the average fluorescence lifetime is 2.78 ns.Conclusion
Because of high stability and low toxicity, GQDs are demonstrated to be excellent bioimaging agents. The ultra-small GQDs can not only distribute in the cytoplasm but also penetrate into the nuclei. We ensure that this work will add a new dimension to the application of graphene materials for nanomedicine.
SUBMITTER: Hong GL
PROVIDER: S-EPMC6113908 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Hong Guo-Lin GL Zhao Hai-Ling HL Deng Hao-Hua HH Yang Hui-Jing HJ Peng Hua-Ping HP Liu Yin-Huan YH Chen Wei W
International journal of nanomedicine 20180824
<h4>Background</h4>The preparation and biological applications of ultra-small graphene quantum dots (GQDs) with accurate-controlled size are of great significance.<h4>Methods</h4>Here in, we report a novel procedure involving pyrolysis of trisodium citrate and subsequent ultrafiltration for fabricating monolayer GQDs with ultra-small lateral size (1.3±0.5 nm).<h4>Results</h4>The GQDs exhibit blue photoluminescence with peak position independent of excitation wavelength. The quantum yield of GQDs ...[more]