Challenges associated with biomarker-based classification systems for Alzheimer's disease.

ABSTRACT:

Introduction

We aimed to evaluate the consistency of the A/T/N classification system.

Methods

We included healthy controls, mild cognitive impairment, and dementia patients from Alzheimer's disease Neuroimaging Initiative. We assessed subject classification consistency with different biomarker combinations and the agreement and correlation between biomarkers.

Results

Subject classification discordance ranged from 12.2% to 44.5% in the whole sample; 17.3%-46.4% in healthy controls; 11.9%-46.5% in mild cognitive impairment, and 1%-35.7% in dementia patients. Amyloid, but not neurodegeneration biomarkers, showed good agreement both in the whole sample and in the clinical subgroups. Amyloid biomarkers were correlated in the whole sample, but not along the Alzheimer's dise

SUBMITTER: Illan-Gala I 

PROVIDER: S-EPMC6114028 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature