Structural Prediction and Mutational Analysis of Rv3906c Gene of Mycobacterium tuberculosis H₃₇Rv to Determine Its Essentiality in Survival.

ABSTRACT: The emergence of tuberculosis is at the peak; therefore to station it at its lower level we hereby try bioinformatics approach against Mycobacterium tuberculosis [M. tuberculosis] pathogenesis. Rv3906c is a conserved hypothetical gene of M. tuberculosis and contains many GTP binding protein motif DXXG which demonstrate that this gene might be processed in a GTP binding or in GTP hydrolyzing manner. This gene shows interaction with its adjacent genes as well as pcnA which is a polymerase and localized in the extracellular region and found to be a soluble protein. Rv3906c has binding pockets for calcium atom at various positions which prove that calcium might have some role during the process of this gene. GTP binding protein motif DXXG is present in various posit

SUBMITTER: Beg MA 

PROVIDER: S-EPMC6114228 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature