New insights into phylogeography of worldwide Brucella canis isolates by comparative genomics-based approaches: focus on Brazil.

ABSTRACT:

Background

Canine brucellosis, due to Brucella canis, is a worldwide zoonosis that remains endemic in South America, including Brazil. Implementation of powerful whole-genome sequencing approaches allowed exploring the Brucella genus considered as monomorphic, with, to date, more than 500 genomes available in public databases. Nevertheless, with under-representation of B. canis genomes -only twenty complete or draft genomes-, lack of knowledge about this species is still considerable. This report describes a comparative genomics-based phylogeographic investigation of 53 B. canis strains, including 28 isolates paired-end sequenced in this work.

Results

Obtained results allow identifying a SNP panel species-specific to B. canis of 1086 nucleotides. In addition, high-resolution

SUBMITTER: Ferreira Vicente A 

PROVIDER: S-EPMC6114238 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature