Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells.

ABSTRACT:

Background

Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese medicine may shed light on design of new therapeutic modes to overcome chemo-resistance. Although Rhizoma Curcumae possesses anti-cancer activities in various types of cancers, the effects and underlying mechanisms of its bioactive components against chemo-resistance are not clear. Therefore, the present study aims to explore the potential effects of Rhizoma Curcumae on doxorubicin-resistant breast cancer cells.

Methods

The expression and function of ABC transporters in doxorubicin-resistant MCF-7 breast cancer cells were measured by western blotting and flo

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC6114245 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature