Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature.

ABSTRACT:

Background

Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia and pleomorphism than the classical type. In the best of our knowledge, a PLC with OGCs has not been previously reported.

Case presentation

We report the case of a 72-year-old woman presenting with a pleomorphic tumor of the left breast with a dense infiltration by OGCs and T lymphocytes with a 10:1 predominance of CD8+ over CD4+ cells. The diagnosis of a lymphoid or mesenchymal neoplasia was excluded after demonstrating keratin expression by the neoplastic cells. The absence of E

SUBMITTER: Pena-Jaimes L 

PROVIDER: S-EPMC6114493 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature