Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling.

ABSTRACT:

Background

Hair follicles (HFs), upon development, undergo repetitive cycles of growth (anagen), regression (catagen), and rest (telogen). The transition between the stages is determined by multiple molecular signals, including DNA methylation, which plays important roles in mammalian cellular identity and is essential for the development of HFs. Secondary hair follicles (SHFs) in cashmere goat exhibit classic cyclic hair development, and little has been done on a genome-wide scale to examine potentially methylated genes involved in the hair cyclic transition.

Results

Genome-wide DNA methylation profiles between skin tissues sampled during the anagen and telogen stages in cashmere goats were investigated using whole-genome bisulfite sequencing (WGBS). The methylation status

SUBMITTER: Li C 

PROVIDER: S-EPMC6114738 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature