PseUI: Pseudouridine sites identification based on RNA sequence information.

ABSTRACT:

Background

Pseudouridylation is the most prevalent type of posttranscriptional modification in various stable RNAs of all organisms, which significantly affects many cellular processes that are regulated by RNA. Thus, accurate identification of pseudouridine (Ψ) sites in RNA will be of great benefit for understanding these cellular processes. Due to the low efficiency and high cost of current available experimental methods, it is highly desirable to develop computational methods for accurately and efficiently detecting Ψ sites in RNA sequences. However, the predictive accuracy of existing computational methods is not satisfactory and still needs improvement.

Results

In this study, we developed a new model, PseUI, for Ψ sites identification in three species, which are H. sapi

SUBMITTER: He J 

PROVIDER: S-EPMC6114832 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature