Genomic meta-analysis of the interplay between 3D chromatin organization and gene expression programs under basal and stress conditions.

ABSTRACT:

Background

Our appreciation of the critical role of the genome's 3D organization in gene regulation is steadily increasing. Recent 3C-based deep sequencing techniques elucidated a hierarchy of structures that underlie the spatial organization of the genome in the nucleus. At the top of this hierarchical organization are chromosomal territories and the megabase-scale A/B compartments that correlate with transcriptional activity within cells. Below them are the relatively cell-type-invariant topologically associated domains (TADs), characterized by high frequency of physical contacts between loci within the same TAD, and are assumed to function as regulatory units. Within TADs, chromatin loops bring enhancers and target promoters to close spatial proximity. Yet, we still have only ru

SUBMITTER: Nurick I 

PROVIDER: S-EPMC6114837 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature