Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria.

ABSTRACT: Neurons contain a high number of mitochondria, these neuronal cells produce elevated levels of oxidative stress and live for a long time without proliferation; therefore, mitochondrial homeostasis is crucial to their health. Investigations have recently focused on mitochondrial dynamics revealing the ability of these organelles to change their distribution and morphology. It is known that mitochondrial fission is necessary for the transmission of mitochondria to daughter cells during mitosis and mitochondrial fragmentation has been used as an indicator of cell death and mitochondrial dysfunction. Oxidative stress is a trigger able to induce changes in the mitochondrial network. The aim of the present study was to determine the effects of melatonin on the mitochondrial network in HT22 serum

SUBMITTER: Cesarini E 

PROVIDER: S-EPMC6114848 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature