Modelling the impact of insecticide-based control interventions on the evolution of insecticide resistance and disease transmission.

ABSTRACT:

Background

Current strategies to control mosquito-transmitted infections use insecticides targeted at various stages of the mosquito life-cycle. Control is increasingly compromised by the evolution of insecticide resistance but there is little quantitative understanding of its impact on control effectiveness. We developed a computational approach that incorporates the stage-structured mosquito life-cycle and allows tracking of insecticide resistant genotypes. This approach makes it possible to simultaneously investigate: (i) the population dynamics of mosquitoes throughout their whole life-cycle; (ii) the impact of common vector control interventions on disease transmission; (iii) how these interventions drive the spread of insecticide resistance; and (iv) the impact of resistance

SUBMITTER: Barbosa S 

PROVIDER: S-EPMC6114906 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature