Prevalence and geographical variation of Factor V Leiden in patients with cerebral venous thrombosis: A meta-analysis.

ABSTRACT:

Background

Previous results regarding the prevalence of Factor V Leiden (FVL) in patients with cerebral venous thrombosis (CVT) varied remarkably. Therefore, we performed a meta-analysis to evaluate the potential association between FVL and CVT.

Methods

The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched for relevant case-control studies. The data were pooled for analysis of the association between FVL and CVT with a random-effects model. Subgroup and sensitivity analyses were performed to evaluate the robustness of the results. Publication bias was assessed by funnel plot and the Egger's test.

Results

A total of 39 case-control studies including 1807 cases of CVT and 7699 control cases were included. FVL was more commo

SUBMITTER: Li X 

PROVIDER: S-EPMC6114929 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature