FGFR3 mRNA overexpression defines a subset of oligometastatic colorectal cancers with worse prognosis.

ABSTRACT:

Objectives

Metastatic colorectal cancer (CRC) remains a leading cause of cancer related deaths. Patients with oligometastatic liver disease represent a clinical subgroup with heterogeneous course. Until now, biomarkers to characterize outcome and therapeutic options have not been fully established.

Methods

We investigated the prevalence of FGFR alterations in a total of 140 primary colorectal tumors and 63 liver metastases of 55 oligometastatic CRC patients. FGF receptors (FGFR1-4) and their ligands (FGF3, 4 and 19) were analyzed for gene amplifications and rearrangements as well as for RNA overexpression in situ. Results were correlated with clinico-pathologic data and molecular subtypes.

Results

Primary tumors showed FGFR1 (6.3%) a

SUBMITTER: Fromme JE 

PROVIDER: S-EPMC6114946 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature