A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy.

ABSTRACT: Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO₂) and gold nanoshell coated silicon nanoparticles for synergistic chemo-photothermal therapy of hypoxia solid tumors. In highly reducing tumor tissues, the outer MnO₂ nanosheet with the loaded drug would be dissociated by intracellular glutathione (GSH), resulting in on-demand drug release, as well as generating Mn²⁺ ions which provided high contrast magnetic resonance imaging (MRI), and fluorescence imaging (FI) in vitro and in vivo. While upon near-infrared (NIR) light irradiation, the gold nanoshell modulated t

SUBMITTER: Zhang TT 

PROVIDER: S-EPMC6114999 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature