Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.

ABSTRACT:

Background

Adiponectin is a hormone secreted by adipose tissue. It regulates glycolysis and lipolysis and is involved in the pathophysiology of diabetes and related disorders. Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32.1) and ADIPOR2 (12p13.33) genes, respectively. In genetic association studies, single nucleotide polymorphisms (SNPs) in or near these genes have been associated with metabolic alterations. However, these relationships are still controversial.

Aim

The aim of this work was to analyze possible associations between ADIPOR1/2 and diabetes and other metabolic disorders.

Methods

A genetic association study was carried out in an admixed Latin American population. A sample of 200 adults

SUBMITTER: Mora-Garcia G 

PROVIDER: S-EPMC6115010 | biostudies-literature | 2017 Summer-Fall

REPOSITORIES: biostudies-literature