A single low dose of hydrocortisone enhances cognitive functioning in HIV-infected women.

ABSTRACT:

Objective

Low-dose hydrocortisone (LDH) enhances aspects of learning and memory in select populations including patients with posttraumatic stress disorder and HIV-infected men. HIV-infected women show impairments in learning and memory, but the cognitive effects of LDH in HIV-infected women are unknown.

Design

Double-blind, placebo-controlled, cross-over study examining the time-dependent effects of a single low-dose administration of hydrocortisone (10 mg oral) on cognition in 36 HIV-infected women. Participants were first randomized to LDH or placebo and then received the opposite treatment one month later.

Methods

Cognitive performance was assessed 30 min and 4 h after pill administration to assess, respectively, nongenomic and genomic effects. Self-reported stres

SUBMITTER: Rubin LH 

PROVIDER: S-EPMC6115286 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature