Association of antiretroviral therapy with brain aging changes among HIV-infected adults.

ABSTRACT:

Objective

Antiretroviral therapy (ART) is currently recommended for all persons living with HIV (PLWH), regardless of their CD4 T-cell count, and should be continued throughout life. Nonetheless, vigilance of the safety of ART, including its neurotoxicity, must continue. We hypothesized that use of certain ART drugs might be associated with aging-related cerebral degenerative changes among PLWH.

Design

Clinicopathological study of PLWH who were using ART drugs at the last clinical assessment.

Methods

Using multivariable logistic regression, we tested associations between use of each specific ART drug (with reference to use of other ART drugs) and cerebral degenerative changes including neuronal phospho-tau lesions, β-amyloid plaque deposition, microgliosis, and astrog

SUBMITTER: Soontornniyomkij V 

PROVIDER: S-EPMC6115290 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature