Comprehensive Investigation on Controlling for CT Imaging Variabilities in Radiomics Studies.

ABSTRACT: Radiomics has shown promise in improving models for predicting patient outcomes. However, to maximize the information gain of the radiomics features, especially in larger patient cohorts, the variability in radiomics features owing to differences between scanners and scanning protocols must be accounted for. To this aim, the imaging variability of radiomics feature values was evaluated on 100 computed tomography scanners at 35 clinics by imaging a radiomics phantom using a controlled protocol and the commonly used chest and head protocols of the local clinic. We used a linear mixed-effects model to determine the degree to which the manufacturer and individual scanners contribute to the overall variability. Using a controlled protocol reduced the overall variability by 57% and 52% compared

SUBMITTER: Ger RB 

PROVIDER: S-EPMC6115360 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature