The invasiveness of human cervical cancer associated to the function of Na_V1.6 channels is mediated by MMP-2 activity.

ABSTRACT: Voltage-gated sodium (Na_V) channels have been related with cell migration and invasiveness in human cancers. We previously reported the contribution of Na_V1.6 channels activity with the invasion capacity of cervical cancer (CeCa) positive to Human Papilloma Virus type 16 (HPV16), which accounts for 50% of all CeCa cases. Here, we show that Na_V1.6 gene (SCN8A) overexpression is a general characteristic of CeCa, regardless of the HPV type. In contrast, no differences were observed in Na_V1.6 channel expression between samples of non-cancerous and cervical intraepithelial neoplasia. Additionally, we found that CeCa cell lines, C33A, SiHa, CaSki and HeLa, express mainly the splice variant of SCN8A that lacks exon 18, shown to encode for an intracellul

SUBMITTER: Lopez-Charcas O 

PROVIDER: S-EPMC6115389 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature