FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.

ABSTRACT: Although many factors contribute to cellular differentiation, the role of mitochondria Ca²⁺ dynamics during development remains unexplored. Because mammalian embryonic epiblasts reside in a hypoxic environment, we intended to understand whether _mCa²⁺ and its transport machineries are regulated during hypoxia. Tissues from multiple organs of developing mouse embryo evidenced a suppression of MICU1 expression with nominal changes on other MCU complex components. As surrogate models, we here utilized human embryonic stem cells (hESCs)/induced pluripotent stem cells (hiPSCs) and primary neonatal myocytes to delineate the mechanisms that control _mCa²⁺ and bioenergetics during development. Analysis of MICU1 expression in hESCs/hiPSCs showed

SUBMITTER: Shanmughapriya S 

PROVIDER: S-EPMC6115453 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature