Growth Factor Proteins and Treatment-Resistant Depression: A Place on the Path to Precision.

ABSTRACT: Background: Since the neurotrophic hypothesis of depression was formulated, conflicting results have been reported regarding the role of growth factor proteins in depressed patients, including whether there are state or trait alterations found in patients compared to controls and whether they represent predictors of treatment response. Recently it has been hypothesized that heterogeneity of findings within this literature might be partly explained by participants' history of treatment-resistant depression. This study aimed to investigate the role of growth factor proteins in patients with treatment-resistant depression (TRD) undergoing an inpatient intervention. Methods: Blood samples were collected from 36 patients with TRD and 36 matched controls. Patients were assessed bot

SUBMITTER: Pisoni A 

PROVIDER: S-EPMC6115516 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature