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Exploration of biocompatible AIEgens from natural resources.

ABSTRACT: Luminogens with aggregation-induced emission (AIEgens) characteristics have been well developed and applied in various areas such as bio-imaging, theranostics, organic photoelectronics and chemo/bio sensors. However, most of the reported AIEgens suffer from the disadvantages of complex organic synthesis and high cost, as well as being environmentally unfriendly and hard to degrade, which have largely limited their real applications. In this work, we discovered berberine chloride, a natural isoquinoline alkaloid isolated from Chinese herbal plants, as an unconventional rotor-free AIEgen with bright solid-state emission and water-soluble characteristics. Single crystal structure analysis and optical property, viscosity, and host-guest interaction studies suggested that intramolecular vibration and twisted intramolecular charge transfer were responsible for the AIE phenomenon of berberine chloride. Moreover, berberine chloride was biocompatible and could specifically target lipid droplets in a fluorescence turn-on and wash-free manner, demonstrating the great potential of natural products as promising AIE probes.

SUBMITTER: Gu Y

PROVIDER: S-EPMC6115644 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Exploration of biocompatible AIEgens from natural resources.

Gu Yuan Y Zhao Zheng Z Su Huifang H Zhang Pengfei P Liu Junkai J Niu Guangle G Li Shiwu S Wang Zhaoyang Z Kwok Ryan T K RTK Ni Xin-Long XL Sun Jingzhi J Qin Anjun A Lam Jacky W Y JWY Tang Ben Zhong BZ

Chemical science 20180629 31

Luminogens with aggregation-induced emission (AIEgens) characteristics have been well developed and applied in various areas such as bio-imaging, theranostics, organic photoelectronics and chemo/bio sensors. However, most of the reported AIEgens suffer from the disadvantages of complex organic synthesis and high cost, as well as being environmentally unfriendly and hard to degrade, which have largely limited their real applications. In this work, we discovered berberine chloride, a natural isoqu ...[more]

PMID: 30310579

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Exploration of biocompatible AIEgens from natural resources.

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Exploration of biocompatible AIEgens from natural resources.

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