A New Criterion for Pediatric AKI Based on the Reference Change Value of Serum Creatinine.

ABSTRACT:

Background

Current definitions of AKI do not take into account serum creatinine's high variability in children.

Methods

We analyzed data from 156,075 hospitalized children with at least two creatinine tests within 30 days. We estimated reference change value (RCV) of creatinine on the basis of age and initial creatinine level in children without kidney disease or known AKI risk, and we used these data to develop a model for detecting pediatric AKI on the basis of RCV of creatinine. We defined pediatric AKI according to pediatric reference change value optimized for AKI in children (pROCK) as creatinine increase beyond RCV of creatinine, which was estimated as the greater of 20 μmol/L or 30% of the initial creatinine level.

Results

Of 102,817 children with at le

SUBMITTER: Xu X 

PROVIDER: S-EPMC6115652 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature