Acute Declines in Renal Function during Intensive BP Lowering and Long-Term Risk of Death.

ABSTRACT:

Background

During intensive BP lowering, acute declines in renal function are common, thought to be hemodynamic, and potentially reversible. We previously showed that acute declines in renal function ≥20% during intensive BP lowering were associated with higher risk of ESRD. Here, we determined whether acute declines in renal function during intensive BP lowering were associated with mortality risk among 1660 participants of the African American Study of Kidney Disease and Hypertension and the Modification of Diet in Renal Disease Trial.

Methods

We used Cox models to examine the association between percentage decline in eGFR (<5%, 5% to <20%, or ≥20%) between randomization and months 3-4 of the trials (period of therapy intensification) and death.

Results

In adjusted

SUBMITTER: Ku E 

PROVIDER: S-EPMC6115661 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature