EGF Receptor-Dependent YAP Activation Is Important for Renal Recovery from AKI.

ABSTRACT:

Background

Increasing evidence indicates that renal recovery from AKI stems from dedifferentiation and proliferation of surviving tubule epithelial cells. Both EGF receptor (EGFR) and the Hippo signaling pathway are implicated in cell proliferation and differentiation, and previous studies showed that activation of EGFR in renal proximal tubule epithelial cells (RPTCs) plays a critical role in recovery from ischemia-reperfusion injury (IRI). In this study, we explored RPTC activation of Yes-associated protein (YAP) and transcriptional coactivator with PDZ binding motif (TAZ), two key downstream effectors of the Hippo pathway, and their potential involvement in recovery from AKI.

Methods

We used immunofluorescence to examine YAP expression in kidney biopsy samples from patien

SUBMITTER: Chen J 

PROVIDER: S-EPMC6115662 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature