Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes.

ABSTRACT: A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described P-stereogenic xantphos derivative as ligand.

SUBMITTER: Sommer H 

PROVIDER: S-EPMC6115688 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature