Pervasive Modulation of Obesity Risk by the Environment and Genomic Background.

ABSTRACT: The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a major role for environmental risk factors. Obesity constitutes a case example of a modern trait shaped by contemporary environment, although with considerable debates about the extent to which gene-by-environment (G×E) interactions accentuate obesity risk in individuals following obesogenic lifestyles. Although interaction effects have been robustly confirmed at the FTO locus, accumulating evidence at the genome-wide level implicates a role for polygenic risk-by-environmen

SUBMITTER: Nagpal S 

PROVIDER: S-EPMC6115725 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature