Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis.

ABSTRACT: Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of diseases. Although an abnormally high RONS level has been identified in keloids - a benign dermal tumour developed after lesion, the ability of employing RONS probes for keloid detection has not yet been exploited. Herein, we report two near-infrared (NIR) fluorescent probes (CyTF and CyBA) that can specifically distinguish keloid fibroblasts from normal dermal fibroblasts. Both CyTF and CyBA show a 15-fold NIR fluorescence enhancement at 717 nm upon reaction with RONS. However, because CyTF has higher specificity towards ONOO^- than CyBA, CyTF can detect stimulated fibroblasts in a more s

SUBMITTER: Cheng P 

PROVIDER: S-EPMC6115726 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature