Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring.

ABSTRACT: Objective: To explore the toxicity of multi-walled carbon nanotubes (MWCNTs) on the liver lipid metabolism of offspring mice and the possible mechanisms involved. Method: Virgin female (16-18 g) and male (18-20 g) C57BL/6 mice were randomly divided into two groups: Control group and Test group. After anesthesia with chloral hydrate, the mice were administered 50 μL saline or dust solution by intratracheal instillation (Control group: 50 μL saline; Test group: 15 mg kg^-1 MWCNTs). Mice were injected with these doses once a week for 13 weeks. Then, male and female mice in the same group were allowed to mate to produce offspring. The pups were fed with normal diet until the end of the experiment (12 weeks old). The offspring mice were sacrificed by decapitation to dete

SUBMITTER: Zhang HY 

PROVIDER: S-EPMC6115901 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature