Assessing the incidence of acidosis in patients receiving metformin with and without risk factors for lactic acidosis.

ABSTRACT:

Background

Despite strong recommendations to use metformin as first-line therapy for type 2 diabetes (T2DM), its use has been suboptimal, likely due to concerns of lactic acidosis. This study compared the association of acidosis in patients with T2DM prescribed metformin with those prescribed other antihyperglycemic medications or no medications.

Methods

This was a retrospective cohort study of patients with newly diagnosed T2DM utilizing an administrative database, which includes medical and prescription claims. Eligible patients had a diagnosis of T2DM, had continuous health plan enrollment 3 months prior to study enrollment and during the study period, and were at least 18 years of age. Mutually exclusive exposure groups were metformin only, other antihyperglycemic medica

SUBMITTER: Trinkley KE 

PROVIDER: S-EPMC6116083 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature