Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope.

ABSTRACT: Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus being potential candidates as antibacterial agents. These comprise lipolytic enzymes that target the mycolic acid-containing outer membrane and peptidoglycan hydrolases responsive to the atypical mycobacterial peptidoglycan layer. In the recent years, a remarkable progress has been made, particularly on the comprehension of the mechanisms of bacteriophage lysis proteins activity and regulation. Notwithstanding, information about mycobacteriophages lysis strategies is limited and is mainly represented by the studies performed with mycobacteri

SUBMITTER: Catalao MJ 

PROVIDER: S-EPMC6116114 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature