Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁵⁸⁻K⁵⁹ Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

ABSTRACT: In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of botulism and represent potential bioweapons; however, they are also recognized pharmaceuticals for the efficient counteraction of hyperactive nerve terminals in a variety of human diseases. The detailed biochemical characterization of subtypes as the basis for development of suitable countermeasures and possible novel therapeutic applications is lagging behind the increase in new subtypes. Here, we report the primary structure of a ninth subtype of BoNT/F. Its amino-acid sequence diverges by at least 8.4% at the holotoxin and 13.4% at the enzymatic domain level from all other

SUBMITTER: Sikorra S 

PROVIDER: S-EPMC6116196 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature