Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses.

ABSTRACT: Lentiviruses are infectious agents of a number of animal species, including sheep, goats, horses, monkeys, cows, and cats, in addition to humans. As in the human case, the host immune response fails to control the establishment of chronic persistent infection that finally leads to a specific disease development. Despite intensive research on the development of lentivirus vaccines, it is still not clear which immune responses can protect against infection. Viral mutations resulting in escape from T-cell or antibody-mediated responses are the basis of the immune failure to control the infection. The innate immune response provides the first line of defense against viral infections in an antigen-independent manner. Antiviral innate responses are conducted by dendritic cells, macrophages, and

SUBMITTER: de Pablo-Maiso L 

PROVIDER: S-EPMC6116218 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature