The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography.

ABSTRACT: Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. With repeat infections throughout life, it can also cause substantial disease in the elderly and in adults with compromised cardiac, pulmonary and immune systems. RSV is a pleomorphic enveloped RNA virus in the Pneumoviridae family. Recently, the three-dimensional (3D) structure of purified RSV particles has been elucidated, revealing three distinct morphological categories: spherical, asymmetric, and filamentous. However, the native 3D structure of RSV particles associated with or released from infected cells has yet to be investigated. In this study, we have established an optimized system for studying RSV structure by imaging RSV-infected cells on transmission electr

SUBMITTER: Ke Z 

PROVIDER: S-EPMC6116276 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature