Survival Prediction in High-grade Osteosarcoma Using Radiomics of Diagnostic Computed Tomography.

ABSTRACT: The poor 5-year survival rate in high-grade osteosarcoma (HOS) has not been increased significantly over the past 30 years. This work aimed to develop a radiomics nomogram for survival prediction at the time of diagnosis in HOS. In this retrospective study, an initial cohort of 102 HOS patients, diagnosed from January 2008 to March 2011, was used as the training cohort. Radiomics features were extracted from the pretreatment diagnostic computed tomography images. A radiomics signature was constructed with the lasso algorithm; then, a radiomics score was calculated to reflect survival probability by using the radiomics signature for each patient. A radiomics nomogram was developed by incorporating the radiomics score and clinical factors. A clinical model was constructed by using clinical f

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6116348 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature