A new nanoscale transdermal drug delivery system: oil body-linked oleosin-hEGF improves skin regeneration to accelerate wound healing.

ABSTRACT:

Background

Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil body particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700-1000 nm in the transgenic safflower seeds. The significant reduction of particle size in transgenic seeds is extremely beneficial to skin absorption.

Results

The diameter of oil body in the transgenic safflower seeds was recorded in the range of 700-1000 nm. The smaller

SUBMITTER: Qiang W 

PROVIDER: S-EPMC6116364 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature