Large-scale in silico identification of drugs exerting sex-specific effects in the heart.

ABSTRACT:

Background

Major differences exist between men and women in both physiology and pathophysiology. Dissecting the underlying processes and contributing mechanisms of sex differences in health and disease represents a crucial step towards precision medicine. Considering the significant differences between men and women in the response to pharmacotherapies, our aim was to develop an in silico model able to predict sex-specific drug responses in a large-scale.

Methods

For this purpose, we focused on cardiovascular effects because of their high morbidity and mortality. Our model predicted several drugs (including acebutolol and tacrine) with significant differences in the heart between men and women. To validate the sex-specific drug responses identified by our model, acebutolol w

SUBMITTER: Cui C 

PROVIDER: S-EPMC6116388 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature