BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study.

ABSTRACT:

Background

BK virus (BKV), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivations are common after kidney transplantation and associated with increased morbidity and mortality. Although CMV might be a risk factor for BKV and EBV, the effects of combined reactivations remain unknown. The purpose of this study is to ascertain the interaction and effects on graft function of these reactivations.

Methods

3715 serum samples from 540 kidney transplant recipients were analysed for viral load by qPCR. Measurements were performed throughout eight visits during the first post-transplantation year. Clinical characteristics, including graft function (GFR), were collected in parallel.

Findings

BKV had the highest prevalence and viral loads. BKV or CMV viral loads over 10

SUBMITTER: Blazquez-Navarro A 

PROVIDER: S-EPMC6116415 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature