The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis.

ABSTRACT:

Background

Cardiovascular disease is a leading cause of death in ANCA-associated vasculitis (AAV). An expansion of CD4⁺CD28^null T cells is seen mainly in cytomegalovirus (CMV)-seropositive individuals and has been linked to increased cardiovascular disease risk in other conditions. The aims of this study were to phenotype CD4⁺CD28^null T cells in AAV with respect to their pro-inflammatory capacity and ability to target and damage the endothelium and to investigate their relationship to arterial stiffness, a marker of cardiovascular mortality.

Methods

CD4⁺CD28^null T cells were phenotyped in 53 CMV-seropositive AAV patients in stable remission and 30 age-matched CMV-seropositive healthy volunteers by flow cytomet

SUBMITTER: Chanouzas D 

PROVIDER: S-EPMC6116544 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature